| Melatonin | Sleep | Reviews suggest it may ease jet lag, and it helps some people with delayed sleep-wake phase disorder. Practice guidelines say the evidence is not strong enough to recommend it for chronic insomnia.Source: NCCIH: Melatonin, What You Need To Know | Limited |
| Ashwagandha | Stress and sleep | In 6 to 8 week studies, people reported less stress and anxiety, often at 500 to 600 mg a day. Sleep gains were small, and extracts have been linked to liver injury in some people.Source: NIH ODS: Ashwagandha (archived copy) | Limited |
| Green tea extract | Weight loss | Its catechins and caffeine may have a modest effect on body weight. Liver injury, though uncommon, has been reported, mostly with extract tablets and capsules.Source: NCCIH: Green Tea | Weak |
| Garcinia cambogia | Appetite and fat loss | ODS says it has little to no effect on weight loss. It seems fairly safe but can cause headache, nausea and stomach symptoms.Source: NIH ODS: Dietary Supplements for Weight Loss (archived copy) | Weak |
| Saw palmetto | Prostate and urinary health | A 2023 review of 27 studies found little or no benefit for enlarged prostate symptoms. One NIH trial raised the dose to three times the usual amount and still saw no improvement.Source: NCCIH: Saw Palmetto | Weak |
| Turmeric (curcumin) | Joint pain | Early evidence for knee osteoarthritis is positive, but better studies are needed. Products vary in how much curcumin they contain, and high-absorption forms have been linked to liver damage.Source: NCCIH: Turmeric | Limited |
| Ginkgo | Memory and focus | NCCIH finds no conclusive evidence that it helps any health condition. Large studies in older adults found it did not lower the risk of dementia.Source: NCCIH: Ginkgo | Weak |
| Bitter orange | Weight loss and energy | Its effect on weight is unclear. Heart attacks, strokes and abnormal heart rhythms have been reported with products containing it, and an FDA analysis found most labeled synephrine amounts were off.Source: NCCIH: Bitter Orange | Avoid |